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No particular dose adjustment advised when tofacitinib coadministered with powerful CYP2C19 inhibitors; lessen tofacitinib dose if coadministered with both equally moderate CYP3A4 and strong CYP2C19 inhibitors .cyclophosphamide will enhance the level or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Impo